Official versions of AutoCAD receive patches and service packs. Portable versions are "frozen in time" or modified by amateurs. You may encounter frequent crashes, corrupted drawing files, or missing features (like the ability to plot to certain printers).
If you are still considering using a portable, cracked version of AutoCAD 2010, here is a direct comparison of the risks versus a legitimate solution: autodesk autocad 2010 portable updated portable
It is worth noting that the portable version of Autodesk AutoCAD 2010 has some differences compared to the full version. The portable version is designed to be highly portable and is optimized for running from a USB drive or other portable storage device. While it offers many of the same features as the full version, it may not have all the bells and whistles. Official versions of AutoCAD receive patches and service